新型抗溃疡药物7-氧代双环（2,2,1）庚-5-烯-3-甲酰氨基-2-羧酸盐（KF-392）对大鼠胃损伤及胃黏膜屏障的影响

Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats.

作者信息

Tanaka H, Suzuki Y, Kojima T, Marumo H

出版信息

Jpn J Pharmacol. 1976 Aug;26(4):403-10. doi: 10.1254/jjp.26.403.

DOI:10.1254/jjp.26.403

Abstract

Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa.

摘要

在大鼠的几种实验性胃溃疡模型中研究了KF-392的抗溃疡作用。结果发现，以1.0至5.0mg/kg口服给予KF-392对Shay溃疡以及阿司匹林、应激和利血平诱导的胃损伤的发展有显著抑制作用。还研究了KF-392对胃黏膜屏障的影响。以上述剂量口服给予KF-392可诱导H+反向扩散进入胃黏膜以及跨黏膜电位差下降。以5.0mg/kg皮下注射给予KF-392对Shay溃疡无抑制作用，也未诱导H+反向扩散进入胃黏膜。

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