西咪替丁可预防因黏膜屏障破坏剂而加重的应激性胃损伤。

Cimetidine protects against stress-induced gastric injury augmented by mucosal barrier breakers.

作者信息

Levine B A, Sirinek K R, Pruitt B A

出版信息

Am J Surg. 1979 Mar;137(3):328-31. doi: 10.1016/0002-9610(79)90060-6.

Abstract

An experimental rat model utilizing cold-restraint stress was employed to test the ability of an H2-receptor antagonist, cimetidine, to control gastric mucosal injury associated with stress augmented by the gastric mucosal barrier breakers, aspirin and taurocholate. Both aspirin and taurocholate, when combined with stress, caused a significant increase in gastric mucosal injury over that seen in animals receiving either stress alone or only gastric mucosal barrier breakers without stress. Pretreatment with cimetidine caused a significant reduction in gastric mucosal injury in stressed animals receiving gastric mucosal barrier breakers. This reduction was to the level of lesions seen in nonstressed animals.

摘要

采用利用冷束缚应激的实验大鼠模型，来测试H2受体拮抗剂西咪替丁控制与由胃黏膜屏障破坏剂阿司匹林和牛磺胆酸盐增强的应激相关的胃黏膜损伤的能力。阿司匹林和牛磺胆酸盐与应激联合使用时，导致胃黏膜损伤比单独接受应激或仅接受无应激的胃黏膜屏障破坏剂的动物显著增加。用西咪替丁预处理可使接受胃黏膜屏障破坏剂的应激动物的胃黏膜损伤显著减少。这种减少达到了非应激动物所见损伤的水平。