Molero T, De La Iglesia S, Santana C, Lemes A, Matutes E
Department of Haematology, Hospital Universitario Ntra. Sra. del Pino, Las Palmas de Gran Canaria, Spain.
Leuk Lymphoma. 1998 Dec;32(1-2):175-7. doi: 10.3109/10428199809059258.
A case of signet-ring cell lymphoma affecting bone marrow is reported. The patient was diagnosed as Waldenström's Macroglobulinaemia on the basis of clinical and laboratory features including morphology, immunohistochemistry and gene rearrangement studies. Light microscopy examination showed cells contained large globular inclusions (signet-ring cells) that stained for kappa immunoglobulin light chain by immunohistochemistry. In addition, the neoplastic cells expressed the common leukocyte antigen CD45 and the B cell marker CD19. This to the best of our knowledge is the first report of a patient with Waldenström's Macroglobulinaemia with the presence of vacuolated signet ring- cells in the bone marrow. Differential diagnosis arises with non-haemopoietic tumours and this needs to be based on specific immunostaining. Tumours and this need to be based on specific immunostaining.
报告了一例累及骨髓的印戒细胞淋巴瘤病例。根据包括形态学、免疫组织化学和基因重排研究在内的临床和实验室特征，该患者被诊断为华氏巨球蛋白血症。光镜检查显示细胞含有大的球状包涵体（印戒细胞），免疫组织化学显示其对κ免疫球蛋白轻链染色。此外，肿瘤细胞表达常见白细胞抗原CD45和B细胞标志物CD19。据我们所知，这是首例华氏巨球蛋白血症患者骨髓中存在空泡化印戒细胞的报告。与非造血肿瘤的鉴别诊断需要基于特异性免疫染色。肿瘤的诊断需要基于特异性免疫染色。
