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滤泡性淋巴瘤的广泛概况：第一部分。

The broad landscape of follicular lymphoma: Part I.

作者信息

Fratoni Stefano, Zanelli Magda, Zizzo Maurizio, Sanguedolce Francesca, Aimola Valentina, Cerrone Giulia, Ricci Linda, Filosa Alessandra, Martino Giovanni, Ascani Stefano

机构信息

Department of Anatomic Pathology, St. Eugenio Hospital of Rome, Rome, Italy.

Pathology Unit, Azienda Unità Sanitaria Locale - IRCCS di Reggio Emilia, Italy.

出版信息

Pathologica. 2020 Mar;112(1):1-16. doi: 10.32074/1591-951X-35-19. Epub 2020 Jan 22.

DOI:10.32074/1591-951X-35-19
PMID:32031179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8138498/
Abstract

Follicular lymphoma is a neoplasm derived from follicle center B cells, typically both centrocytes and centroblasts, in variable proportions according to the lymphoma grading. The pattern of growth may be entirely follicular, follicular and diffuse, and rarely completely diffuse. It represents the second most common non-Hodgkin lymphoma, after diffuse large B-cell lymphoma and is the most common low-grade mature B-cell lymphoma in western countries. In the majority of cases, follicular lymphoma is a nodal tumor, occurring in adults and frequently associated with the translocation t(14;18)(q32;q21)/IGH-BCL2. However, in recent years the spectrum of follicular lymphoma has expanded and small subsets of follicular lymphoma, which differ from common follicular lymphoma, have been identified and included in the current 2017 WHO classification. The aim of our review is to describe the broad spectrum of follicular lymphoma, pointing out that the identification of distinct clinicopathological variants of follicular lymphoma is relevant for patient outcomes and choice of treatment.

摘要

滤泡性淋巴瘤是一种起源于滤泡中心B细胞的肿瘤，通常包括中心细胞和中心母细胞，其比例根据淋巴瘤分级而有所不同。生长模式可能完全呈滤泡状、滤泡状与弥漫性混合，很少完全呈弥漫性。它是继弥漫性大B细胞淋巴瘤之后第二常见的非霍奇金淋巴瘤，也是西方国家最常见的低级别成熟B细胞淋巴瘤。在大多数情况下，滤泡性淋巴瘤是一种淋巴结肿瘤，发生于成年人，常与t(14;18)(q32;q21)/IGH-BCL2易位相关。然而，近年来滤泡性淋巴瘤的谱系有所扩展，已识别出与常见滤泡性淋巴瘤不同的滤泡性淋巴瘤小亚群，并将其纳入2017年世界卫生组织的现行分类中。我们综述的目的是描述滤泡性淋巴瘤的广泛谱系，指出识别滤泡性淋巴瘤不同的临床病理变异型对患者的预后和治疗选择具有重要意义。

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本文引用的文献

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2
The exomic landscape of t(14;18)-negative diffuse follicular lymphoma with 1p36 deletion.伴有1p36缺失的t(14;18)阴性弥漫性滤泡性淋巴瘤的外显子组图谱
Br J Haematol. 2018 Feb;180(3):391-394. doi: 10.1111/bjh.15041. Epub 2017 Nov 28.
3
Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.
Pathologica. 2020 Jun;112(2):79-92. doi: 10.32074/1591-951X-6-20. Epub 2020 Mar 12.
双打击滤泡淋巴瘤的临床病理和基因组分析：与伴有 MYC 和 BCL2 及/或 BCL6 重排的高级别 B 细胞淋巴瘤的比较。
Mod Pathol. 2018 Feb;31(2):313-326. doi: 10.1038/modpathol.2017.134. Epub 2017 Oct 6.
4
Epstein-Barr virus-positive follicular lymphoma.爱泼斯坦-巴尔病毒阳性滤泡性淋巴瘤
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Double-hit follicular lymphoma with MYC and BCL2 translocations: a study of 7 cases with a review of literature.伴有MYC和BCL2易位的双打击滤泡性淋巴瘤：7例病例研究并文献复习
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