de Nully Brown P, Hansen M M
Department of Hematology, Rigshospitalet, Copenhagen, Denmark.
Leuk Lymphoma. 1999 Jan;32(3-4):365-8. doi: 10.3109/10428199909167398.
The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on the number of granulocytes in peripheral blood and myeloid cells in the bone marrow were studied in seven patients with chronic lymphocytic leukemia (CLL). The neutrophil count in the peripheral blood rose by a median of 193% (range 142-980%), p = 0.02, and the increase persisted for more than 2 weeks after discontinuation of the treatment. The percentage of myeloid cells in bone marrow increased by 166% (range--57-1800%). In neutropenic CLL patients with recurrent infections GM-CSF treatment may constitute a new treatment modality.
研究了粒细胞巨噬细胞集落刺激因子（GM-CSF）对7例慢性淋巴细胞白血病（CLL）患者外周血粒细胞数量及骨髓髓系细胞的影响。外周血中性粒细胞计数中位数升高了193%（范围142%-980%），p = 0.02，且在治疗中断后升高持续超过2周。骨髓中髓系细胞百分比增加了166%（范围-57%-1800%）。对于有反复感染的中性粒细胞减少的CLL患者，GM-CSF治疗可能构成一种新的治疗方式。
