粒细胞-巨噬细胞集落刺激因子可提高慢性淋巴细胞白血病患者血清中β2-微球蛋白和胸苷激酶的水平。
GM-CSF raises serum levels of beta 2-microglobulin and thymidine kinase in patients with chronic lymphocytic leukaemia.
作者信息
Itälä M, Pelliniemi T T, Remes K
机构信息
Department of Medicine, Turku University Central Hospital, Finland.
出版信息
Br J Haematol. 1996 Jul;94(1):129-32. doi: 10.1046/j.1365-2141.1996.6172066.x.
The effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) on biochemical tumour markers beta 2-microglobulin (beta 2m), thymidine kinase (TK) and lactate dehydrogenase (LDH) were studied in eight patients with chronic lymphocytic leukaemia (CLL). The serum concentration of beta 2m rose by a median of 30% (range 8-50%) and serum TK by 101% (range 30-1414%). Serum LDH concentration, on the other hand, significantly decreased in all patients. The significant increases of beta 2m and TK could not be explained by progression of the disease or impaired renal function. Treatment with GM-CSF reduces the value of serum beta 2m and TK in assessment of tumour mass and disease activity.
在8例慢性淋巴细胞白血病（CLL）患者中研究了粒细胞巨噬细胞集落刺激因子（GM-CSF）对生化肿瘤标志物β2-微球蛋白（β2m）、胸苷激酶（TK）和乳酸脱氢酶（LDH）的影响。β2m的血清浓度中位数升高了30%（范围8%-50%），血清TK升高了101%（范围30%-1414%）。另一方面，所有患者的血清LDH浓度均显著降低。β2m和TK的显著升高无法用疾病进展或肾功能受损来解释。GM-CSF治疗降低了血清β2m和TK在评估肿瘤大小和疾病活动中的数值。
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