Alster T S, Manaloto R M
Washington Institute of Dermatologic Laser Surgery, Washington, DC, USA.
Dermatol Surg. 1999 Feb;25(2):133-5. doi: 10.1046/j.1524-4725.1999.08097.x.
Nodular amyloidosis is a rare form of primary localized cutaneous amyloidosis which is characterized by single or multiple nodules located on the extremities, trunk, genitalia, or face.
To determine the clinical and histologic response of nodular amyloidosis to pulsed dye laser treatment.
Biopsy-proven amyloid nodules were treated with a 585-nm pulsed dye laser (average fluence 5.25 J/cm2; 10 mm spot) at 6- to 8-week time intervals. Clinical and histologic examination of laser-irradiated nodules were performed before and 6 weeks after the final laser treatment.
Clinical improvement in the color, size, and pliability of nodules was noted and maintained for 6 months. Histologic examination revealed decreased inflammation and improvement in dermal collagen after laser irradiation.
Since amyloid fibrils may be formed in association with dermatan sulfate-an essential matrix component in collagen fiber formation, it is postulated that the improvement seen in amyloid nodules after pulsed dye laser treatment may be attributed to a mechanism similar to that seen with hypertrophic scars.
结节性淀粉样变性是原发性局限性皮肤淀粉样变性的一种罕见形式，其特征为在四肢、躯干、生殖器或面部出现单个或多个结节。
确定结节性淀粉样变性对脉冲染料激光治疗的临床和组织学反应。
经活检证实的淀粉样结节，每隔6至8周用585纳米脉冲染料激光（平均能量密度5.25 J/cm²；光斑10毫米）进行治疗。在最后一次激光治疗前及治疗后6周，对激光照射过的结节进行临床和组织学检查。
结节的颜色、大小和柔韧性有临床改善，并维持了6个月。组织学检查显示激光照射后炎症减轻，真皮胶原有所改善。
由于淀粉样纤维可能与硫酸皮肤素相关形成，而硫酸皮肤素是胶原纤维形成中必不可少的基质成分，因此推测脉冲染料激光治疗后淀粉样结节出现的改善可能归因于与肥厚性瘢痕类似的机制。
