Wong A M, Sharpe J A
Department of Ophthalmology, The Toronto Hospital and the University of Toronto, Ontario, Canada.
Arch Ophthalmol. 1999 Feb;117(2):208-17. doi: 10.1001/archopht.117.2.208.
To evaluate the retinotopic map of the human occipital cortex by correlating magnetic resonance imaging (MRI) findings with visual field defects in patients with occipital lobe infarcts and to assess the compatibility between our cliniconeuroimaging findings and the location of lesions predicted by the classic Holmes map and a revised map.
Magnetic resonance images were obtained in 14 patients with occipital lobe infarcts. Visual field analysis was performed with tangent screen, the Goldmann perimeter, and the Humphrey Field Analyzer. Based on the pattern of visual field deficit, the location of the lesion in the mesial occipital lobe in each patient was predicted using the Holmes map and other retinotopic maps of the occipital cortex. The predicted location of the lesion was then compared with its actual location shown on MRI to assess the compatibility between our data and the other maps. These maps determine retinotopic correlates of the medial occipital lobe, but they cannot establish correlates of the striate cortex (V1). The medial occipital representation of central vision was evaluated by regression analysis.
The MRI correlations in this study confirmed gross estimates of the retinotopic organization of the occipital cortex. However, our findings did not correlate exactly with the Holmes map. We determined that the central 15 degrees of vision occupies 37% of the total surface area of the human medial occipital lobe. Based on our data, a refined retinotopic map is presented.
The resolution of conventional MRI testifies to its considerable value in localizing occipital lobe lesions. Our findings support, and refine, the Holmes map of the human occipital cortex.
通过将磁共振成像（MRI）结果与枕叶梗死患者的视野缺损进行关联，评估人类枕叶皮质的视网膜定位图，并评估我们的临床神经影像学发现与经典霍姆斯图及修订图所预测的病变位置之间的兼容性。
对14例枕叶梗死患者进行了磁共振成像检查。使用正切屏、戈德曼视野计和汉弗莱视野分析仪进行视野分析。根据视野缺损模式，使用霍姆斯图及其他枕叶皮质视网膜定位图预测每位患者枕叶内侧病变的位置。然后将预测的病变位置与其在MRI上显示的实际位置进行比较，以评估我们的数据与其他图谱之间的兼容性。这些图谱确定了枕叶内侧的视网膜定位相关性，但无法确定纹状皮质（V1）的相关性。通过回归分析评估中央视觉的枕叶内侧表征。
本研究中的MRI相关性证实了枕叶皮质视网膜定位组织的大致估计。然而，我们的发现与霍姆斯图并不完全相关。我们确定中央15度视野占人类枕叶内侧总面积的37%。基于我们的数据，提出了一幅精确的视网膜定位图。
传统MRI的分辨率证明了其在定位枕叶病变方面的重要价值。我们的发现支持并完善了人类枕叶皮质的霍姆斯图。
