Yanagisawa J, Yanagi Y, Masuhiro Y, Suzawa M, Watanabe M, Kashiwagi K, Toriyabe T, Kawabata M, Miyazono K, Kato S
Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Science. 1999 Feb 26;283(5406):1317-21. doi: 10.1126/science.283.5406.1317.
Cell proliferation and differentiation are regulated by growth regulatory factors such as transforming growth factor-beta (TGF-beta) and the liphophilic hormone vitamin D. TGF-beta causes activation of SMAD proteins acting as coactivators or transcription factors in the nucleus. Vitamin D controls transcription of target genes through the vitamin D receptor (VDR). Smad3, one of the SMAD proteins downstream in the TGF-beta signaling pathway, was found in mammalian cells to act as a coactivator specific for ligand-induced transactivation of VDR by forming a complex with a member of the steroid receptor coactivator-1 protein family in the nucleus. Thus, Smad3 may mediate cross-talk between vitamin D and TGF-beta signaling pathways.
细胞增殖和分化受生长调节因子调控，如转化生长因子-β（TGF-β）和亲脂性激素维生素D。TGF-β可激活SMAD蛋白，这些蛋白在细胞核中作为共激活因子或转录因子发挥作用。维生素D通过维生素D受体（VDR）控制靶基因的转录。Smad3是TGF-β信号通路下游的SMAD蛋白之一，在哺乳动物细胞中发现它通过与细胞核中类固醇受体共激活因子-1蛋白家族的一个成员形成复合物，作为VDR配体诱导反式激活的特异性共激活因子发挥作用。因此，Smad3可能介导维生素D和TGF-β信号通路之间的相互作用。
