Liu Huidong, Chen Ye-Guang
The State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, 100084, China.
Front Cell Dev Biol. 2022 Mar 9;10:846723. doi: 10.3389/fcell.2022.846723. eCollection 2022.
The transforming growth factor-β (TGF-β) signaling plays a critical role in the development and tissue homeostasis in metazoans, and deregulation of TGF-β signaling leads to many pathological conditions. Mounting evidence suggests that TGF-β signaling can actively alter metabolism in diverse cell types. Furthermore, metabolic pathways, beyond simply regarded as biochemical reactions, are closely intertwined with signal transduction. Here, we discuss the role of TGF-β in glucose, lipid, amino acid, redox and polyamine metabolism with an emphasis on how TGF-β can act as a metabolic modulator and how metabolic changes can influence TGF-β signaling. We also describe how interplay between TGF-β signaling and cell metabolism regulates cellular homeostasis as well as the progression of multiple diseases, including cancer.
转化生长因子-β（TGF-β）信号通路在多细胞动物的发育和组织稳态中起着关键作用，TGF-β信号通路失调会导致许多病理状况。越来越多的证据表明，TGF-β信号通路可积极改变多种细胞类型的代谢。此外，代谢途径不仅仅被视为生化反应，还与信号转导紧密相连。在此，我们讨论TGF-β在葡萄糖、脂质、氨基酸、氧化还原和多胺代谢中的作用，重点关注TGF-β如何作为代谢调节剂发挥作用以及代谢变化如何影响TGF-β信号通路。我们还描述了TGF-β信号通路与细胞代谢之间的相互作用如何调节细胞稳态以及包括癌症在内的多种疾病的进展。
