Sutow W W, George S, Lowman J T, Starling K A, Humphrey G B, Haggard M E, Vietti T J
Med Pediatr Oncol. 1976;2(4):387-95. doi: 10.1002/mpo.2950020405.
Six regimens utilizing L-asparaginase in doses of 6,000 IU/M2, 2,000 IU/M2, and 500 IU/M2 in two separate schedules (consecutive and intermittent) along with vincristine and prednisone yielded remarkably similar response rates, approximating 70%, in 306 previously treated children with acute leukemia in relapse. The addition of daunorubicin to one regimen did not alter the response rate. Hypersensitivity reactions occurred in 5% and hyperglycemia in 7%. Lower doses of L-asparaginase significantly reduced the hypersensitivity rate but no such pattern was noted for hyperglycemia. A history of prior resistance to prednisone and vincristine significantly reduced the response rate.
六种方案使用剂量分别为6000 IU/M²、2000 IU/M²和500 IU/M²的L-天冬酰胺酶，分两种不同给药方案（连续和间歇），同时联合长春新碱和泼尼松，对306例既往接受过治疗且处于复发期的急性白血病儿童进行治疗，结果显示缓解率非常相似，接近70%。在一种方案中加入柔红霉素并未改变缓解率。5%的患者出现过敏反应，7%的患者出现高血糖。较低剂量的L-天冬酰胺酶显著降低了过敏反应发生率，但高血糖未呈现此规律。既往对泼尼松和长春新碱耐药的病史显著降低了缓解率。
