Trueworthy R C, Sutow W W, Pullen J, Komp D, Berry D H
Med Pediatr Oncol. 1978;4(2):91-7. doi: 10.1002/mpo.2950040202.
The capacity of 1-asparaginase in two separate schedules (consecutive and intermittent), along with vincristine and prednisone to produce multiple responses, was evaluated in previously treated children with acute leukemia in relapse. The response rates varied inversely with previous 1-asparaginase exposure. A history of prior resistance to prednisone and vincristine appeared to reduce the response rate. Hypersensitivity reactions occurred in 14%.
在先前接受过治疗且复发的急性白血病患儿中，评估了两种不同给药方案（连续和间歇）下的左旋门冬酰胺酶联合长春新碱和泼尼松产生多种反应的能力。缓解率与先前左旋门冬酰胺酶的使用情况呈负相关。既往对泼尼松和长春新碱耐药的病史似乎会降低缓解率。14%的患儿出现了过敏反应。
