Raberger G, Schütz W, Zimpfer M
Naunyn Schmiedebergs Arch Pharmacol. 1976 Oct;295(1):51-4. doi: 10.1007/BF00509772.
The effects of ouabain on intact and experimentally constricted coronary arteries were investigated in anaesthetized, thoracotomized dogs. Ouabain decreased the blood flow in the intact artery without changing the flow per beat values and increased flow in the constricted artery. Since ouabain decreased left ventricular enddiastolic pressure, it is proposed that the drug-induced augmentation of flow in the constricted artery is related to an elevation of driving pressure to the endocardial layers of the myocardium which are supplied by the constricted artery.
在麻醉开胸犬身上研究了哇巴因对完整及实验性狭窄冠状动脉的作用。哇巴因使完整动脉的血流量减少，而不改变每搏流量值，并使狭窄动脉的血流量增加。由于哇巴因降低了左心室舒张末期压力，因此有人提出，药物引起的狭窄动脉血流量增加与狭窄动脉所供应的心肌心内膜层驱动压力升高有关。
