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盐酸阿米替林治疗焦虑症、失眠症及用作镇静剂

[Amitriptyline hydrochloride in the treatment of anxiety and insomnia and as a tranquilizer].

作者信息

Aurón Zaltzman D

出版信息

Neurol Neurocir Psiquiatr. 1976;17(3):165-9.

PMID:1004682
Abstract

An open, non-comparative study with weekly clinical evaluations was made in 30 patients of both sexes aged between 16 and 70 years. The only medication used to treat anxiety was Amytryptiline HCl. 23 patients completed 12 weeks of treatment and 7 abandoned it before completion. Dosages varied between 25 and 100 mg daily, with median dose being 50 mg. Twenty-three patients showed mild side effects that disappeared without specific treatment. Improvement began the first or second week; at the end of 12 weeks, 17 patients were considered cured, 16 improved and 7 with no change.

摘要

对30名年龄在16至70岁之间的男女患者进行了一项开放性、非对照性研究,每周进行临床评估。治疗焦虑症唯一使用的药物是盐酸阿米替林。23名患者完成了12周的治疗,7名患者在治疗结束前放弃。剂量为每日25至100毫克,中位剂量为50毫克。23名患者出现轻度副作用,未经特殊治疗即消失。改善始于第一周或第二周;在12周结束时,17名患者被认为治愈,16名患者有所改善,7名患者无变化。

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