Scharf M B, Hirschowitz J, Zemlan F P, Lichstein M, Woods M
J Clin Psychiatry. 1986 Dec;47(12):587-91.
Chlordiazepoxide-amitriptyline (Limbitrol) has been shown to be more rapidly effective than amitriptyline alone for treating depression. A double-blind, randomized study was designed to compare the effects of Limbitrol and amitriptyline on insomnia, anxiety, and depression. The rate of improvement of symptoms was faster with Limbitrol. No differences were noted between groups in the degree or rate of improvement of the sleep laboratory parameters nor in sleep Stages 1 to 4. Percentages of rapid eye movement (REM) sleep and REM latency were similarly affected by the drugs, but REM density showed a significantly greater decrease with Limbitrol. Phasic REM factors may be crucial in the role of REM sleep and depression.
氯氮卓-阿米替林（利眠宁）已被证明在治疗抑郁症方面比单独使用阿米替林起效更快。一项双盲、随机研究旨在比较利眠宁和阿米替林对失眠、焦虑和抑郁的影响。利眠宁组症状改善速度更快。两组在睡眠实验室参数改善程度或速度以及睡眠1至4期方面均未发现差异。快速眼动（REM）睡眠百分比和REM潜伏期受药物影响相似，但利眠宁组的REM密度显著降低。REM睡眠的相位因素可能在REM睡眠与抑郁症的关系中起关键作用。
