Herman J E, Fleischmann P
Isr J Med Sci. 1978 Aug;14(8):848-51.
A hypersensitivity reaction to orally administered phenoxymethyl penicillin is reported. The manifestations of the reaction included fever, arthralgia, urticaria and an irregular pulse. Serial ECG showed second-degree atrioventricular block with junctional escape beats, an atypical Wenckebach pattern and, finally, first-degree atrioventricular block with gradually decreasing PR intervals. A normal tracing was recorded on the sixth day despite the persistence of the rash and joint pains.
据报道，有患者对口服苯氧甲基青霉素出现超敏反应。该反应的表现包括发热、关节痛、荨麻疹和脉搏不规则。连续心电图显示二度房室传导阻滞伴交界性逸搏、非典型文氏现象，最终发展为一度房室传导阻滞且PR间期逐渐缩短。尽管皮疹和关节疼痛持续存在，但在第六天记录到心电图恢复正常。
