Sakurai K, Hata S, Amano S, Fukuzawa M
1st Department of Surgery, Nihon University School of Medicine.
Nihon Shokakibyo Gakkai Zasshi. 1999 Jan;96(1):8-13.
We evaluated the clinical significance of p16 and Ki-67 expressions in esophageal squamous cell carcinomas. Operative specimens obtained from 64 patients with esophageal squamous cell carcinomas were investigated by staining with antibodies against p16 and Ki-67. The possible correlations among p16 and Ki-67 expression, clinicopathologic factors and prognosis were studied. The expression of p16 was observed in 68.9%, and it related to histologic classification, lymphatic invasion and clinicopathological stage. Survival rate was significantly better in the patients with p16 positive tumors than in those with p16 negative tumors. Ki-67 positive index (Ki-67-PI) related to only histologic classification. It is suggested that immunohistochemical assessment on the p16 expressions would be useful to select more suitable treatment of squamous cell carcinoma of the esophagus.
我们评估了p16和Ki-67表达在食管鳞状细胞癌中的临床意义。对64例食管鳞状细胞癌患者的手术标本进行了p16和Ki-67抗体染色研究。研究了p16和Ki-67表达、临床病理因素与预后之间的可能相关性。观察到p16表达率为68.9%，其与组织学分类、淋巴浸润及临床病理分期有关。p16阳性肿瘤患者的生存率显著高于p16阴性肿瘤患者。Ki-67阳性指数（Ki-67-PI）仅与组织学分类有关。提示对p16表达进行免疫组化评估有助于选择更合适的食管鳞状细胞癌治疗方案。
