Wang Lianghai, Li Jing, Yu Xiaodan, Zhang Zhiyu, Pang Lijuan, Li Shugang, Hou Jun, Li Feng
Department of Pathology & Key Laboratories for Xinjiang Endemic & Ethnic Diseases, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Department of Preventive Medicine, Shihezi University School of Medicine, Shihezi, Xinjiang, China.
Biomark Med. 2016 May;10(5):537-46. doi: 10.2217/bmm-2015-0057. Epub 2016 Apr 13.
The prognostic value of p16(INK4A) in esophageal squamous cell carcinoma (ESCC) has been evaluated for several years although the results remain controversial.
Various databases were systematically searched to identify studies published on the p16(INK4A) survival rate of ESCC patients. The pooled risk ratios and odds ratios with their corresponding 95% CIs were used to estimate the effect sizes.
A total of 16 studies comprising 1314 patients were included. p16(INK4A) overexpression was significantly associated with improved 5-year overall survival, disease-free survival, early tumor TNM stages, better tumor histological grade, no lymph node metastasis and more shallow tumor invasive depth (p < 0.05).
p16(INK4A) expression could be a useful biomarker to predict better prognosis for ESCC patients.
尽管结果仍存在争议，但p16（INK4A）在食管鳞状细胞癌（ESCC）中的预后价值已被评估多年。
系统检索各种数据库，以识别已发表的关于ESCC患者p16（INK4A）生存率的研究。采用合并风险比和比值比及其相应的95%置信区间来估计效应大小。
共纳入16项研究，包括1314例患者。p16（INK4A）过表达与改善5年总生存率、无病生存率、早期肿瘤TNM分期、更好的肿瘤组织学分级、无淋巴结转移以及更浅的肿瘤浸润深度显著相关（p < 0.05）。
p16（INK4A）表达可能是预测ESCC患者更好预后的有用生物标志物。
