Ku N N
Department of Pathology, University of South Florida College of Medicine, Tampa 33612, USA.
Curr Opin Obstet Gynecol. 1999 Feb;11(1):41-3. doi: 10.1097/00001703-199901000-00008.
The cervical Papanicolaou (Pap) smear is the most effective and inexpensive cancer screening test in medical history for the identification of premalignant cervicovaginal lesions. Despite this fact, false-negative rates ranging from 6% to 55% have been sporadically reported, resulting in an increase in litigation. With the development of computer-based automated technology, a significant proportion of such false-negative results have been reduced by rescreening of negative smears. This article reviews the automated technology approved by the USA Food and Drug Administration and its use, including performance, accuracy and cost-effectiveness compared with the results of conventional manual screening.
宫颈巴氏涂片检查是医学史上用于识别宫颈阴道癌前病变最有效且成本低廉的癌症筛查测试。尽管如此，仍有零星报道称假阴性率在6%至55%之间，这导致了诉讼案件的增加。随着基于计算机的自动化技术的发展，通过对阴性涂片进行重新筛查，很大一部分此类假阴性结果已有所减少。本文回顾了美国食品药品监督管理局批准的自动化技术及其应用，包括与传统手工筛查结果相比的性能、准确性和成本效益。
