Bendall L J, Gottlieb D J
Department of Hematology, University of Sydney at Westmead Hospital, New South Wales, Australia.
Leuk Lymphoma. 1999 Feb;32(5-6):427-39. doi: 10.3109/10428199909058400.
CD44 has long been implicated in the interaction between hematopoietic progenitors and bone marrow stroma. More recently it has become apparent that CD44 antibodies cannot only inhibit CD44 mediated adhesion to hyaluronic acid and cellular ligands but can stimulate adhesion to these ligands. The mechanism involved in CD44 antibody stimulated adhesion to cellular layers is still not known. While adhesion of T cells to keratinocytes is integrin mediated it appears that adhesion of hematopoietic progenitors to bone marrow stromal layers is the result of an antibody induced conformational change in the CD44 molecule similar to that seem for the augmentation of hyaluronic acid binding by some CD44 antibodies. The ligand for CD44 involved in this binding has not been identified but it does not appear to be hyaluronic acid.
长期以来，CD44一直被认为参与造血祖细胞与骨髓基质之间的相互作用。最近，越来越明显的是，CD44抗体不仅可以抑制CD44介导的对透明质酸和细胞配体的粘附，还可以刺激对这些配体的粘附。CD44抗体刺激对细胞层粘附所涉及的机制尚不清楚。虽然T细胞对角质形成细胞的粘附是由整合素介导的，但造血祖细胞对骨髓基质层的粘附似乎是CD44分子中抗体诱导的构象变化的结果，类似于一些CD44抗体增强透明质酸结合时所看到的情况。参与这种结合的CD44配体尚未确定，但似乎不是透明质酸。
