Douglas S, Cortina-Borja M, Cartwright R
University Department of Medicine and Therapeutics University of Aberdeen, Scotland, UK.
Leuk Lymphoma. 1999 Feb;32(5-6):523-32. doi: 10.3109/10428199909058410.
The literature on presentation of seasonality of leukaemia fails to provide clear conclusions. Using the Data Collection Study organised by the Leukaemia Research Fund (LRF) Centre for Clinical Epidemiology, University of Leeds, this question was re-examined. This data has a high level of ascertainment and is population based. The results were mainly negative, there being no fit to a sinusoidal curve (Cosinor analysis) in any part of the data. Using normal approximation to Poisson there were individual months with positive findings. Such a method could not be specifically depended on to provide reliable conclusions, nevertheless, further work in this area is justified. Non-Hodgkin's lymphoma was also examined but again with mainly negative findings.
关于白血病季节性表现的文献未能给出明确结论。利用由利兹大学白血病研究基金会（LRF）临床流行病学中心组织的数据收集研究，对这一问题进行了重新审视。该数据的确定程度很高且基于人群。结果主要为阴性，数据的任何部分均不符合正弦曲线（余弦分析）。使用泊松分布的正态近似法，个别月份有阳性发现。然而，不能特别依赖这种方法来提供可靠结论，尽管如此，该领域的进一步研究仍有必要。还对非霍奇金淋巴瘤进行了检查，但结果同样主要为阴性。
