Blair V, Birch J M
Cancer Research Campaign Paediatric and Familial Cancer Research Group, Christie Hospital NHS Trust, Manchester, U.K.
Eur J Cancer. 1994;30A(10):1490-8. doi: 10.1016/0959-8049(94)00274-9.
Patterns and trends in incidence of leukaemia and lymphoma in children aged under 15 years and resident in the North Western Regional Health Authority area of England at diagnosis, over the 35-year time period 1954-1988, were analysed. The study included 1407 cases registered with the Manchester Children's Tumour Registry, 100% of which had a histologically or cytologically verified diagnosis. Log-linear modelling identified significant linear increases in acute lymphocytic leukaemia (ALL) (average quinquennial increase 4%) and Hodgkin's disease (HD) (10%), but not in acute non-lymphocytic leukaemia nor non-Hodgkin's lymphoma. Additionally, the chi 2 test for trend identified a significant increase in the incidence of chronic myeloid leukaemia. The possibility that the increases seen in ALL and HD are linked to increases in prevalence of unknown infectious agents is discussed.
对1954年至1988年这35年期间，居住在英格兰西北地区卫生局辖区内、诊断时年龄在15岁以下儿童的白血病和淋巴瘤发病率模式及趋势进行了分析。该研究纳入了在曼彻斯特儿童肿瘤登记处登记的1407例病例，其中100%的病例经组织学或细胞学确诊。对数线性模型确定急性淋巴细胞白血病（ALL）（平均每五年增加4%）和霍奇金病（HD）（10%）有显著线性增加，但急性非淋巴细胞白血病和非霍奇金淋巴瘤无此情况。此外，趋势的卡方检验确定慢性粒细胞白血病发病率有显著增加。文中讨论了ALL和HD发病率增加与未知传染原流行率增加相关的可能性。
