Tanaka E
Institute of Community Medicine, University of Tsukuba, Ibaraki-ken, Japan.
J Clin Pharm Ther. 1998 Dec;23(6):403-16. doi: 10.1046/j.1365-2710.1998.00086.x.
Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues and many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. After coadministration, some drugs act as potent enzyme inducers, whereas others are inhibitors. However, reports of enzyme inhibition are very much more common. Understanding these mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple-drug therapies. In the future, it may help to identify individuals at greatest risk of drug interactions and adverse events.
药物相互作用已成为医疗保健领域的一个重要问题。现在人们认识到，许多药物相互作用可以通过肝脏和其他肝外组织中存在的代谢酶的改变来解释，并且药物之间的许多主要药代动力学相互作用是由于肝细胞色素P450（P450或CYP）酶受到先前使用的其他药物的影响。联合给药后，一些药物作为强效酶诱导剂，而其他药物则是抑制剂。然而，酶抑制的报道要普遍得多。了解这些酶抑制或诱导机制对于进行适当的多药治疗极为重要。未来，它可能有助于识别药物相互作用和不良事件风险最高的个体。
