细胞色素 P450 在药物相互作用中的作用。
Role of cytochrome P450 in drug interactions.
机构信息
Department of Chemistry, University of Karachi, Karachi-75270, Pakistan.
出版信息
Nutr Metab (Lond). 2008 Oct 18;5:27. doi: 10.1186/1743-7075-5-27.
Abstract
Drug-drug interactions have become an important issue in health care. It is now realized that many drug-drug interactions can be explained by alterations in the metabolic enzymes that are present in the liver and other extra-hepatic tissues. Many of the major pharmacokinetic interactions between drugs are due to hepatic cytochrome P450 (P450 or CYP) enzymes being affected by previous administration of other drugs. After coadministration, some drugs act as potent enzyme inducers, whereas others are inhibitors. However, reports of enzyme inhibition are very much more common. Understanding these mechanisms of enzyme inhibition or induction is extremely important in order to give appropriate multiple-drug therapies. In future, it may help to identify individuals at greatest risk of drug interactions and adverse events.
摘要
药物-药物相互作用已成为医疗保健中的一个重要问题。现在人们已经认识到，许多药物-药物相互作用可以通过改变存在于肝脏和其他肝外组织中的代谢酶来解释。许多药物之间的主要药代动力学相互作用是由于先前给予其他药物而导致肝细胞色素 P450（P450 或 CYP）酶受到影响。合用后，一些药物作为有效的酶诱导剂，而另一些则是抑制剂。然而，关于酶抑制的报道要常见得多。为了给予适当的多药物治疗，了解这些酶抑制或诱导的机制是非常重要的。将来，它可能有助于识别发生药物相互作用和不良事件风险最大的个体。
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