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本文引用的文献

1
Validation of an improved reversed-phase high-performance liquid chromatography assay with reductive electrochemical detection for the determination of artemisinin derivatives in man.一种改进的反相高效液相色谱法结合还原电化学检测用于测定人体青蒿素衍生物的方法验证
Ther Drug Monit. 1998 Feb;20(1):109-16. doi: 10.1097/00007691-199802000-00020.
2
Pharmacokinetics of oral artesunate in children with moderately severe Plasmodium falciparum malaria.口服青蒿琥酯在中度严重恶性疟原虫疟疾患儿中的药代动力学
Trans R Soc Trop Med Hyg. 1997 Mar-Apr;91(2):195-8. doi: 10.1016/s0035-9203(97)90222-4.
3
Effect of food intake on pharmacokinetics of oral artemisinin in healthy Vietnamese subjects.食物摄入对健康越南受试者口服青蒿素药代动力学的影响。
Antimicrob Agents Chemother. 1997 May;41(5):1069-72. doi: 10.1128/AAC.41.5.1069.
4
Pharmacokinetics of artemisinin and artesunate after oral administration in healthy volunteers.青蒿素和青蒿琥酯在健康志愿者口服给药后的药代动力学。
Am J Trop Med Hyg. 1997 Jan;56(1):17-23. doi: 10.4269/ajtmh.1997.56.17.
5
Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria.青蒿素及其衍生物在疟疾治疗中的临床药理学与治疗潜力。
Drugs. 1996 Dec;52(6):818-36. doi: 10.2165/00003495-199652060-00004.
6
Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients.青蒿素口服多剂量药代动力学及其与青蒿琥酯口服剂在恶性疟患者中疗效的比较。
Trans R Soc Trop Med Hyg. 1996 Jan-Feb;90(1):61-5. doi: 10.1016/s0035-9203(96)90480-0.
7
Selective high-performance liquid chromatographic determination of artesunate and alpha- and beta-dihydroartemisinin in patients with falciparum malaria.用选择性高效液相色谱法测定恶性疟患者体内的青蒿琥酯、α-和β-二氢青蒿素
J Chromatogr B Biomed Appl. 1996 Mar 3;677(2):345-50. doi: 10.1016/0378-4347(95)00428-9.
8
[Pharmacokinetics of dihydroqinghaosu in human volunteers and comparison with qinghaosu].双氢青蒿素在人体志愿者中的药代动力学及其与青蒿素的比较
Yao Xue Xue Bao. 1993;28(5):342-6.
9
Single day mefloquine-artesunate combination in the treatment of multi-drug resistant falciparum malaria.单剂量甲氟喹-青蒿琥酯联合疗法治疗多重耐药恶性疟
Trans R Soc Trop Med Hyg. 1994 Mar-Apr;88(2):213-7. doi: 10.1016/0035-9203(94)90303-4.
10
Treatment of multidrug-resistant Plasmodium falciparum malaria with 3-day artesunate-mefloquine combination.采用青蒿琥酯-甲氟喹三日疗法治疗多重耐药恶性疟
J Infect Dis. 1994 Oct;170(4):971-7. doi: 10.1093/infdis/170.4.971.

用青蒿琥酯口服治疗恶性疟5天期间，血浆中双氢青蒿素浓度下降。

Declining concentrations of dihydroartemisinin in plasma during 5-day oral treatment with artesunate for Falciparum malaria.

作者信息

Khanh N X, de Vries P J, Ha L D, van Boxtel C J, Koopmans R, Kager P A

机构信息

Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam.

出版信息

Antimicrob Agents Chemother. 1999 Mar;43(3):690-2. doi: 10.1128/AAC.43.3.690.

DOI:10.1128/AAC.43.3.690
PMID:10049291
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89184/
Abstract

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.

摘要

6例无并发症的恶性疟患者接受了5天的青蒿琥酯治疗。采用高效液相色谱-电化学检测法测定血浆中青蒿琥酯和双氢青蒿素的浓度。给药后2小时血浆中双氢青蒿素浓度呈时间依赖性下降。血浆中青蒿琥酯浓度，尤其是最后一剂后浓度非常低。尽管如此，所有患者均迅速康复。