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阿莫西林-克拉维酸对从鼻窦炎患者上颌窦穿刺标本中分离出的需氧菌和厌氧菌的体外比较活性。

Comparative in vitro activities of amoxicillin-clavulanate against aerobic and anaerobic bacteria isolated from antral puncture specimens from patients with sinusitis.

作者信息

Goldstein E J, Citron D M, Merriam C V

机构信息

R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA.

出版信息

Antimicrob Agents Chemother. 1999 Mar;43(3):705-7. doi: 10.1128/AAC.43.3.705.

Abstract

By an agar dilution method, the antimicrobial susceptibilities of antral sinus puncture isolates were studied. Pneumococci were generally susceptible to amoxicillin, azithromycin, and clarithromycin, but 17% of pneumococcal isolates were resistant to cefuroxime. Haemophilus influenzae isolates were resistant to amoxicillin and clarithromycin. beta-Lactamase production occurred in 69% of Prevotella species. One-third of Peptostreptococcus magnus isolates were resistant to azithromycin and clarithromycin. Cefuroxime had limited activity against Prevotella species and P. magnus. Levofloxacin was active against most isolates except peptostreptococci. Amoxicillin-clavulanate was active against all isolates, with the MIC at which 90% of the isolates were inhibited being < or = 1 microgram/ml.

摘要

采用琼脂稀释法研究了鼻窦穿刺分离株的抗菌药敏情况。肺炎球菌通常对阿莫西林、阿奇霉素和克拉霉素敏感,但17%的肺炎球菌分离株对头孢呋辛耐药。流感嗜血杆菌分离株对阿莫西林和克拉霉素耐药。69%的普雷沃菌属产生β-内酰胺酶。三分之一的大消化链球菌分离株对阿奇霉素和克拉霉素耐药。头孢呋辛对普雷沃菌属和大消化链球菌的活性有限。左氧氟沙星对除消化链球菌外的大多数分离株有活性。阿莫西林-克拉维酸对所有分离株均有活性,90%分离株被抑制的最低抑菌浓度≤1微克/毫升。

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