Goldstein E J, Citron D M, Merriam C V
R. M. Alden Research Laboratory, Santa Monica-UCLA Medical Center, Santa Monica, California 90404, USA.
Antimicrob Agents Chemother. 1999 Mar;43(3):705-7. doi: 10.1128/AAC.43.3.705.
By an agar dilution method, the antimicrobial susceptibilities of antral sinus puncture isolates were studied. Pneumococci were generally susceptible to amoxicillin, azithromycin, and clarithromycin, but 17% of pneumococcal isolates were resistant to cefuroxime. Haemophilus influenzae isolates were resistant to amoxicillin and clarithromycin. beta-Lactamase production occurred in 69% of Prevotella species. One-third of Peptostreptococcus magnus isolates were resistant to azithromycin and clarithromycin. Cefuroxime had limited activity against Prevotella species and P. magnus. Levofloxacin was active against most isolates except peptostreptococci. Amoxicillin-clavulanate was active against all isolates, with the MIC at which 90% of the isolates were inhibited being < or = 1 microgram/ml.
采用琼脂稀释法研究了鼻窦穿刺分离株的抗菌药敏情况。肺炎球菌通常对阿莫西林、阿奇霉素和克拉霉素敏感,但17%的肺炎球菌分离株对头孢呋辛耐药。流感嗜血杆菌分离株对阿莫西林和克拉霉素耐药。69%的普雷沃菌属产生β-内酰胺酶。三分之一的大消化链球菌分离株对阿奇霉素和克拉霉素耐药。头孢呋辛对普雷沃菌属和大消化链球菌的活性有限。左氧氟沙星对除消化链球菌外的大多数分离株有活性。阿莫西林-克拉维酸对所有分离株均有活性,90%分离株被抑制的最低抑菌浓度≤1微克/毫升。