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二氧化碳对红霉素的影响。

Effect of carbon dioxide on erythromycin.

作者信息

Goldstein E J, Sutter V L

出版信息

Antimicrob Agents Chemother. 1983 Feb;23(2):325-7. doi: 10.1128/AAC.23.2.325.

DOI:10.1128/AAC.23.2.325
PMID:6404220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186047/
Abstract

Exposure of erythromycin solutions to CO(2) or air for 18 h resulted in minimal deterioration under both conditions. Saturated disks exposed to the two atmospheres resulted in greater erythromycin deterioration, with slightly more deterioration occurring in the presence of CO(2). Reduction of activity was greatest when assays were conducted in a CO(2) environment.

摘要

将红霉素溶液暴露于二氧化碳或空气中18小时，在两种条件下均导致最小程度的降解。暴露于这两种气氛下的饱和滤纸片导致红霉素降解更严重，在有二氧化碳存在时降解稍多。当在二氧化碳环境中进行测定时，活性降低最大。

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本文引用的文献

1
Effect of carbon dioxide on in vitro susceptibility of anaerobic bacteria to erythromycin.二氧化碳对厌氧菌体外对红霉素敏感性的影响。
Antimicrob Agents Chemother. 1981 Dec;20(6):705-8. doi: 10.1128/AAC.20.6.705.
2
The effect of carbon dioxide on the sensitivity of Bacteroides fragilis to certain antibiotics in vitro.二氧化碳对脆弱拟杆菌体外某些抗生素敏感性的影响。
J Clin Pathol. 1970 Apr;23(3):254-8. doi: 10.1136/jcp.23.3.254.
3
Effect of pH on the activity of erythromycin against 500 isolates of gram-negative bacilli.pH对红霉素针对500株革兰氏阴性杆菌活性的影响。
Appl Microbiol. 1970 Nov;20(5):754-6. doi: 10.1128/am.20.5.754-756.1970.
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Effect of pH of medium and size of inoculum on activity of antibiotics against group D Streptococcus (Enterococcus).培养基pH值和接种量大小对D组链球菌（肠球菌）抗生素活性的影响。
Appl Microbiol. 1970 Apr;19(4):629-37. doi: 10.1128/am.19.4.629-637.1970.
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Excretion of erythromycin and its enhanced activity in urine against gram-negative bacilli with alkalinization.
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Susceptibility of Bacteroides fragilis to six antibiotics determined by standardized antimicrobial disc susceptibility testing.通过标准化抗菌药敏试验测定脆弱拟杆菌对六种抗生素的敏感性。
Antimicrob Agents Chemother. 1973 Feb;3(2):188-93. doi: 10.1128/AAC.3.2.188.
7
Effect of several components of anaerobic incubation on antibiotic susceptibility test results.
Antimicrob Agents Chemother. 1972 May;1(5):433-40. doi: 10.1128/AAC.1.5.433.
8
Effect of carbon dioxide on synthesis of erythromycin.二氧化碳对红霉素合成的影响。
Antimicrob Agents Chemother. 1974 May;5(5):544-5. doi: 10.1128/AAC.5.5.544.
9
The susceptibility of Bacteroides fragilis to 24 antibiotics.脆弱拟杆菌对24种抗生素的敏感性
J Infect Dis. 1972 Mar;125(3):295-9. doi: 10.1093/infdis/125.3.295.
10
Susceptibility of anaerobic bacteria to 23 antimicrobial agents.厌氧菌对23种抗菌剂的敏感性。
Antimicrob Agents Chemother. 1976 Oct;10(4):736-52. doi: 10.1128/AAC.10.4.736.