Warren B A, Lytton D G
Pathology. 1976 Jul;8(3):231-45. doi: 10.3109/00313027609059004.
Eroded atheromatous plaques which have released atheromatous material into the circulation are commonly found at autopsy in the abdominal aorta and common iliac arteries in man. In an attempt to study this phenomenon quantitatively, human atheromatous material in suspension was injected intothe femoral and common iliac arteries in rabbits. The weight of atheromatous material injected was varied. There was a critical load for the common iliac artery beyond which there was progressive ascending thrombosis and death of the animal. In rabbits weighing 3 to 5 kg, up to 0.2 g of atheromatous material could be injected intra-arterially with survival of the animal and without producing observable effects. As the amount was increased there was a narrow zone in which survival of the animal with a limp occurred. Beyond 0.2 g, death resulted from ascending thrombosis of the peripheral limb arteries. This eventually reached the bifurcation of the oarta and obstructed the opposite common iliac artery. A thrombus rapidly formed around the atheromatous material. Examination of the atherothrombus by light, transmission electron and scanning electron microscopy showed that it contained cholesterol crystals, lipid material, many platelets, leucocytes and red cells bound together within a fibrin net. The atheromatous material was for the most part in the core of the thrombus.
尸检时通常会在人的腹主动脉和髂总动脉中发现已向循环系统释放粥样物质的糜烂性动脉粥样硬化斑块。为了定量研究这一现象，将悬浮状态的人类粥样物质注入兔子的股动脉和髂总动脉。注入的粥样物质重量各不相同。髂总动脉存在一个临界负荷，超过该负荷会出现进行性上行血栓形成并导致动物死亡。在体重3至5千克的兔子中，动脉内注入高达0.2克的粥样物质时，动物能够存活且未产生可观察到的影响。随着注入量增加，存在一个狭窄区域，动物在此区域存活但出现跛行。超过0.2克时，动物因外周肢体动脉上行血栓形成而死亡，血栓最终到达主动脉分叉处并阻塞对侧髂总动脉。粥样物质周围迅速形成血栓。通过光学显微镜、透射电子显微镜和扫描电子显微镜检查动脉粥样血栓发现，其包含胆固醇晶体、脂质物质、许多血小板、白细胞和红细胞，它们在纤维蛋白网内结合在一起。粥样物质大部分位于血栓核心部位。
