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兔动脉斑块的血栓形成。一项电子显微镜研究。

Thrombogenesis of the rabbit arterial plaque. An electron microscopic study.

作者信息

Stemerman M B

出版信息

Am J Pathol. 1973 Oct;73(1):7-26.

PMID:4584129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1904041/
Abstract

Rabbit arteries, de-endothelialized with an intravascular balloon catheter and allowed to heal for 4 weeks, showed intimal changes that were similar to the preatherosclerotic fibromusculoelastic plaques of man. Reinjury of the healed vessels by balloon catheter produced marked quantitative and qualitative alterations of hemostasis, as compared to that in previously uninjured vessels. The most apparent modification of thrombogenesis 10 minutes after injury to the plaque was a large increase in the size of the thrombotic deposits. Features of this exaggerated response were the major participation of fibrin in thrombus formation and greater platelet accumulation. Some platelets and fibrin strands appeared to penetrate into and beneath the neointima. By 3 hours, these deposits had diminished in size, although the hemostatic mass remained larger in the doubly injured vessels.

摘要

用血管内球囊导管去除内皮的兔动脉，使其愈合4周后，显示出与人类动脉粥样硬化前期纤维肌弹性斑块相似的内膜变化。与先前未损伤的血管相比，球囊导管对愈合血管的再次损伤导致止血出现明显的数量和质量改变。斑块损伤后10分钟，血栓形成最明显的改变是血栓沉积物大小大幅增加。这种过度反应的特征是纤维蛋白在血栓形成中起主要作用以及血小板聚集增加。一些血小板和纤维蛋白丝似乎渗透到新内膜内和其下方。到3小时时，这些沉积物的大小有所减小，尽管在再次损伤的血管中止血团块仍然较大。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/5b05b008888c/amjpathol00248-0024-a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/c652682c8df8/amjpathol00248-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/26bec28f8e30/amjpathol00248-0025-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/ad1fbbf0f871/amjpathol00248-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/faecce2aa0c9/amjpathol00248-0030-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/40d617af2ee9/amjpathol00248-0027-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/e53f6ec9db2e/amjpathol00248-0027-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/a8ff38f8419e/amjpathol00248-0023-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/86f2/1904041/dcc70972a3a0/amjpathol00248-0028-a.jpg
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本文引用的文献

1
NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA.动脉内皮细胞中的新细胞质成分
J Cell Biol. 1964 Oct;23(1):101-12. doi: 10.1083/jcb.23.1.101.
2
PREATHEROMA PHASE OF CORONARY ATHEROSCLEROSIS IN MAN.人类冠状动脉粥样硬化的脂纹前期阶段。
Exp Mol Pathol. 1964 Oct;3:475-84. doi: 10.1016/0014-4800(64)90028-0.
3
The fine structure of human atherosclerotic lesions.人类动脉粥样硬化病变的精细结构。
Am J Pathol. 1980 Apr;99(1):81-104.
4
Vascular smooth muscle cell growth kinetics in vivo in aged rats.
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3863-6. doi: 10.1073/pnas.79.12.3863.
5
Organizational behavior of human umbilical vein endothelial cells.人脐静脉内皮细胞的组织行为
J Cell Biol. 1982 Sep;94(3):511-20. doi: 10.1083/jcb.94.3.511.
6
Ultrastructural changes in re-endothelialized and non-endothelialized rabbit aortic neo-intima following re-injury with a balloon catheter.球囊导管再次损伤后兔主动脉再内皮化和未内皮化新生内膜的超微结构变化
Br J Exp Pathol. 1984 Oct;65(5):597-611.
7
Role of shear rate and platelets in promoting fibrin formation on rabbit subendothelium. Studies utilizing patients with quantitative and qualitative platelet defects.
J Clin Invest. 1986 Oct;78(4):1072-82. doi: 10.1172/JCI112663.
8
Distribution of cellular responses in rabbit aortae following one and two injuries with a balloon catheter.用球囊导管对兔主动脉进行一次和两次损伤后细胞反应的分布情况
Br J Exp Pathol. 1988 Jun;69(3):351-65.
9
Early proto-oncogene expression in rat aortic smooth muscle cells following endothelial removal.内皮去除后大鼠主动脉平滑肌细胞中早期原癌基因的表达。
Am J Pathol. 1990 Oct;137(4):761-5.
10
Atheromatous emboli in renal biopsies. An ultrastructural study.肾活检中的动脉粥样硬化栓子。一项超微结构研究。
Am J Pathol. 1975 Feb;78(2):261-76.
Am J Pathol. 1961 Mar;38(3):263-87.
4
The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.以过氧化物酶为示踪剂研究毛细血管通透性的超微结构基础。
J Cell Biol. 1967 Oct;35(1):213-36. doi: 10.1083/jcb.35.1.213.
5
[Effects of vascular catheterization in normo- and hypercholesteremic rabbits].[血管插管对正常胆固醇血症和高胆固醇血症兔的影响]
Pathol Microbiol (Basel). 1966;29(4):393-405.
6
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Am J Pathol. 1971 Mar;62(3):391-414.
7
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8
Tissue factor (thromboplastin): localization to plasma membranes by peroxidase-conjugated antibodies.组织因子（凝血致活酶）：通过过氧化物酶偶联抗体定位于质膜。
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9
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