Pal'tsev A I, Nepomniashchikh D L
Med Parazitol (Mosk). 1998 Oct-Dec(4):28-32.
The paper analyzes the clinical course of hepatitis, laboratory and morphological changes in 312 patients with the disease in the presence of chronic opisthorchiasis, including 277 with chronic persistent hepatitis and 35 with chronic active hepatitis. The intensity of a hepatic inflammatory process depended on the duration and number of infections. The greatest changes were observed in superinfections, then in reinfections. They were less profound in primary infection. A picture of chronic active hepatitis with signs of dystrophy, necrobiosis, and necrosis of cells was revealed in patients with super infections by morphological studies. Sclerotic changes with focal destruction of the organ and abnormal reconstruction of the lobar architecture were most significant in patients with reinvasion. Hepatocytic dystrophy in the absence of inflammation was more common in prolonged opisthorchiasis with low infection rates. The findings suggest that opisthorchiasis-associated hepatitis should be included into the current classification.
本文分析了312例患有慢性后睾吸虫病的肝炎患者的临床病程、实验室检查及形态学变化，其中包括277例慢性持续性肝炎患者和35例慢性活动性肝炎患者。肝脏炎症过程的强度取决于感染的持续时间和次数。重叠感染时变化最为明显，其次是再感染，初次感染时变化则较轻。形态学研究显示，重叠感染患者出现了伴有细胞营养不良、渐进性坏死和坏死迹象的慢性活动性肝炎表现。再感染患者中，器官局灶性破坏和叶结构异常重建的硬化性变化最为显著。在感染率较低的长期后睾吸虫病患者中，无炎症的肝细胞营养不良更为常见。研究结果表明，与后睾吸虫病相关的肝炎应纳入当前分类。
