Dargent D, Bremond A, Rudigoz R G, Beau G E
Nouv Presse Med. 1976 Nov 27;5(40):2691-3.
Ninety nine cases of carcinoma in situ of the cervix are reported. In all cases, the definitive diagnosis was established after study of an operative specimen (cone biopsy or hysterectomy) examined by serial section. Pre-operative cytology was falsely negative (or suggestive of simple dysplasia) in 35,4 per cent of cases and pre-operative biopsy falsely negative in 40 per cent. These errors were approximately twice as common in cases in which dysplasia was present in association with the caricinoma (40 cases) than in those cases in which the malignancy alone was present (59 cases). The practical conclusions which may be drawn from these findings in relation to detection and diagnosis are discussed.
报告了99例宫颈原位癌。所有病例均在对手术标本（锥形活检或子宫切除术）进行连续切片检查后确立了明确诊断。术前细胞学检查在35.4%的病例中呈假阴性（或提示单纯发育异常），术前活检在40%的病例中呈假阴性。这些错误在伴有发育异常的癌病例（40例）中大约是仅存在恶性肿瘤病例（59例）的两倍。讨论了从这些关于检测和诊断的发现中可以得出的实际结论。
