Gao D M, Benazzouz A, Piallat B, Bressand K, Ilinsky I A, Kultas-Ilinsky K, Benabid A L
Department of Physiology, Jinzhou Medical College, Liaoning, People's Republic of China.
Neuroscience. 1999 Jan;88(1):201-12. doi: 10.1016/s0306-4522(98)00235-8.
The effect of high-frequency stimulation of the subthalamic nucleus on parkinsonian-like resting tremor was investigated in two monkeys (Macaca fascicularis). Unilateral tremor of the arm and leg was induced by electrical coagulation of the brainstem area including the substantia nigra and the red nucleus. The tremor was only seen at rest condition with a very stable frequency of 4.46+/-0.59 Hz (mean+/-S.D.). Apomorphine (0.10-0.4 mg/kg, s.c.) completely blocked the tremor, suggesting that it was a dopaminergic-dependent symptom just like the parkinsonian tremor. When the stimulating frequency varied from 20 to 1000 Hz, both mono- and bipolar stimulation (square pulses, 0-5 mA, 0.06 ms) of the subthalamic nucleus suppressed resting tremor in a frequency-dependent manner but monopolar stimulation was more effective. These effects remained stable for more than two years. The present results suggest that the subthalamic nucleus is involved in the control and mechanism of resting tremor and that the high-frequency stimulation of the subthalamic nucleus can be used as an alternative therapy in parkinsonian patients with akinesia, rigidity and resting tremor.
在两只猕猴（食蟹猴）中研究了高频刺激丘脑底核对帕金森样静止性震颤的影响。通过电凝包括黑质和红核在内的脑干区域诱发手臂和腿部的单侧震颤。震颤仅在静止状态下出现，频率非常稳定，为4.46±0.59Hz（平均值±标准差）。阿扑吗啡（0.10 - 0.4mg/kg，皮下注射）可完全阻断震颤，表明其与帕金森震颤一样是一种多巴胺能依赖性症状。当刺激频率在20至1000Hz之间变化时，丘脑底核的单极和双极刺激（方波脉冲，0 - 5mA，0.06ms）均以频率依赖性方式抑制静止性震颤，但单极刺激更有效。这些效果在两年多的时间里保持稳定。目前的结果表明，丘脑底核参与静止性震颤的控制和机制，高频刺激丘脑底核可作为帕金森病患者运动不能、强直和静止性震颤的替代治疗方法。
