Jablecka A, Chmara E, Korzeniowska K
Department of Clinical Pharmacology, University of Medical Sciences, Poznan, Dluga, Poland.
Int J Clin Pharmacol Res. 1998;18(4):171-8.
The concentrations of adrenaline, noradrenaline, dopamine, aldosterone, the atrial natriuretic hormone, and plasma renin activity were investigated in 50 patients with mild chronic heart failure. The patients received oral digoxin chronically in a daily dose of 0.125 mg. On the basis of the estimate of the dosing of digoxin these patients were divided into two groups: the first with therapeutic and the second with subtherapeutic concentrations of digoxin in serum. The therapeutic concentration of digoxin in serum was found in 23 patients (46%), while subtherapeutic levels were found in 27 patients (54%). The concentrations of noradrenaline, dopamine, the renin activity of plasma, aldosterone and the atrial natriuretic hormone in the blood serum in the group of patients in whom the presence of subtherapeutic concentrations of digoxin was found, did not differ essentially from the concentration that was observed in the group with therapeutic concentrations. Only the concentration of adrenaline was higher (p < 0.05) in the group of patients with therapeutic concentrations of digoxin. The above results reveal that the neuroendocrine activity of plasma (except for the concentration of adrenaline) is alike in both ranges of digoxin concentrations in serum.
对50例轻度慢性心力衰竭患者的肾上腺素、去甲肾上腺素、多巴胺、醛固酮、心房利钠肽和血浆肾素活性浓度进行了研究。这些患者长期口服地高辛，日剂量为0.125mg。根据地高辛的给药剂量估计，将这些患者分为两组：第一组血清地高辛浓度处于治疗水平，第二组血清地高辛浓度处于亚治疗水平。23例患者（46%）血清地高辛浓度处于治疗水平，27例患者（54%）血清地高辛浓度处于亚治疗水平。血清地高辛浓度处于亚治疗水平的患者组中，血清去甲肾上腺素、多巴胺、血浆肾素活性、醛固酮和心房利钠肽的浓度与血清地高辛浓度处于治疗水平的患者组中观察到的浓度相比，无本质差异。仅血清地高辛浓度处于治疗水平的患者组中肾上腺素浓度较高（p<0.05）。上述结果表明，血清地高辛浓度的两个范围内，血浆神经内分泌活性（肾上腺素浓度除外）相似。
