Cochereau I, Belayachi N, Diraison C, Matheron S, Bouyer I, Hoang-Xuan T, Saimot A G, Coulaud J P
Service d'Ophtalmologie, Hôpital Bichat-Claude Bernard, Paris.
J Fr Ophtalmol. 1998 Dec;21(10):723-6.
To assess the tolerability and efficacy of intravitreal injections of foscarnet in cytomegalovirus (CMV) retinitis in acquired immunodeficiency syndrome (AIDS).
Patients with CMV retinitis resistant and/or intolerant to intravenous foscarnet and ganciclovir and resistant to intravitreal ganciclovir were included. The induction therapy consisted of intravitreal injections of 2,400 micrograms of foscarnet twice a week. The assessment was performed by clinical examination and photographies of the fundus.
Three patients (four eyes) have been included. Three eyes were administered seven and one eye eight intravitreal injections. The tolerability was good, but the efficacy was mere: the retinal lesions became less edematous, but they still extended.
In these four eyes with CMV retinitis resistant to intravitreal ganciclovir, intravitreal injections of foscarnet were well tolerated but did not stop the progression of the retinitis.
评估玻璃体内注射膦甲酸钠治疗获得性免疫缺陷综合征（AIDS）患者巨细胞病毒（CMV）视网膜炎的耐受性和疗效。
纳入对静脉注射膦甲酸钠和更昔洛韦耐药和/或不耐受且对玻璃体内注射更昔洛韦耐药的CMV视网膜炎患者。诱导治疗包括每周两次玻璃体内注射2400微克膦甲酸钠。通过临床检查和眼底照相进行评估。
纳入3例患者（4只眼）。3只眼接受了7次玻璃体内注射，1只眼接受了8次注射。耐受性良好，但疗效一般：视网膜病变水肿减轻，但仍有扩展。
在这4只对玻璃体内注射更昔洛韦耐药的CMV视网膜炎眼中，玻璃体内注射膦甲酸钠耐受性良好，但未能阻止视网膜炎进展。
