Song Y J, Sawamura M, Ikeda K, Igawa S, Nara Y, Yamori Y
Graduate School of Human and Environmental Studies, Kyoto University.
Appl Human Sci. 1998 Nov;17(6):275-80. doi: 10.2114/jpa.17.275.
Exercise improves muscle insulin sensitivity and GLUT4 contents. We investigated the beneficial effects of swimming training on insulin sensitivity and genetic hypertension using stroke-prone hypertensive rats (SHRSP). We studied the relationship between genetic hypertension and insulin resistance in SHRSP and Wistar Kyoto rats (WKY) as a control. The systolic blood pressure of SHRSP was significantly reduced by 4-week swimming training (208.4 +/- 6.8 mmHg vs. 187.2 +/- 4.1 mmHg, p < 0.05). The swimming training also resulted in an approximately 20% increase in the insulin-stimulated glucose transport activity (p < 0.05) of soleus muscle strips and an approximately 3-fold increase in the plasma membrane GLUT4 protein expression (p < 0.01) in SHRSP. However, basal and insulin-stimulated glucose transport activity and GLUT4 contents were not significantly different between WKY and SHRSP. There was no difference in insulin resistance in skeletal muscle of SHRSP as compared with WKY. Our results indicated swimming training exercise improved not only hypertension but also muscle insulin sensitivity and GLUT4 protein expression in SHRSP.
运动可提高肌肉胰岛素敏感性和葡萄糖转运蛋白4（GLUT4）含量。我们使用易中风高血压大鼠（SHRSP）研究了游泳训练对胰岛素敏感性和遗传性高血压的有益作用。我们研究了SHRSP和作为对照的Wistar Kyoto大鼠（WKY）中遗传性高血压与胰岛素抵抗之间的关系。通过4周的游泳训练，SHRSP的收缩压显著降低（208.4±6.8 mmHg对187.2±4.1 mmHg，p<0.05）。游泳训练还使SHRSP比目鱼肌条的胰岛素刺激的葡萄糖转运活性增加了约20%（p<0.05），质膜GLUT4蛋白表达增加了约3倍（p<0.01）。然而，WKY和SHRSP之间的基础和胰岛素刺激的葡萄糖转运活性以及GLUT4含量没有显著差异。与WKY相比，SHRSP骨骼肌中的胰岛素抵抗没有差异。我们的结果表明，游泳训练运动不仅改善了SHRSP的高血压，还提高了肌肉胰岛素敏感性和GLUT4蛋白表达。
