Hugues F C, Julien D, Munera Y, Ginnsz A, Marche J
Poumon Coeur. 1976;32(5):215-9.
The authors report the results of a study of propranolol perfused intravenously at a dose of 1 mcg/kg/mn during 30 mn to 50 asthmatic patients. The VC decreased by 8.3 and by 10.9% in the middle and at the end of the perfusion. The FEV1 decreased by 18.3 and 23% concomitantly. Classifying patients in 4 groups according to the clinical severeness of the asthma showed that the response to propranolol increased with that severenesse. Exploration of obstructive bronchopneumopathies by propranolol provided valuable data or the differential diagnosis of asthma and chronic bronchitis.
作者报告了一项对50名哮喘患者进行的研究结果,该研究中以1微克/千克/分钟的剂量静脉输注普萘洛尔,持续30分钟。在输注过程中及结束时,肺活量(VC)分别下降了8.3%和10.9%。第一秒用力呼气容积(FEV1)相应地分别下降了18.3%和23%。根据哮喘的临床严重程度将患者分为4组,结果显示对普萘洛尔的反应随严重程度增加。用普萘洛尔对阻塞性支气管肺病进行检查为哮喘和慢性支气管炎的鉴别诊断提供了有价值的数据。