King A, May J, Phillips I
Microbiology Department, UMDS, London, UK.
J Antimicrob Chemother. 1998 Dec;42(6):711-9. doi: 10.1093/jac/42.6.711.
Quinupristin/dalfopristin and RPR 106972 were active in vitro against a wide range of aerobic Gram-positive organisms including Enterococcus faecium. However, most isolates of Enterococcus faecalis were resistant or of intermediate sensitivity. Against Staphylococcus aureus quinupristin/dalfopristin was more active but for all other species the range of activity of the two drugs was the same or RPR 106972 was more active. RPR 106972 was also more active against the respiratory pathogens Haemophilus influenzae and Moraxella catarrhalis. Quinupristin/dalfopristin MICs for isolates of H. influenzae (1-8 mg/L) clustered around the breakpoint. There were differences in the quality of growth, but little difference in MICs or zone diameters was obtained on three different media: Mueller-Hinton (MHA), Iso-Sensitest (ISA), and Diagnostic Sensitivity Test (DST) agars. The addition of blood to the medium increased MICs 2- to 4-fold, with MHA showing the greatest increase, and reduced zone diameters around quinupristin/dalfopristin discs by 3-4 mm, with the greatest effect on ISA.
奎奴普丁/达福普汀和RPR 106972在体外对包括粪肠球菌在内的多种需氧革兰氏阳性菌具有活性。然而，大多数粪肠球菌分离株具有抗性或中度敏感。对于金黄色葡萄球菌，奎奴普丁/达福普汀活性更强，但对于所有其他菌种，两种药物的活性范围相同或RPR 106972活性更强。RPR 106972对呼吸道病原体流感嗜血杆菌和卡他莫拉菌也更具活性。流感嗜血杆菌分离株的奎奴普丁/达福普汀MIC值（1 - 8mg/L）集中在折点附近。生长质量存在差异，但在三种不同培养基（穆勒-欣顿琼脂（MHA）、异感测试琼脂（ISA）和诊断敏感性测试琼脂（DST））上，MIC值或抑菌圈直径差异不大。向培养基中添加血液会使MIC值增加2至4倍，其中MHA增加幅度最大，并且会使奎奴普丁/达福普汀纸片周围的抑菌圈直径减小3至4mm，对ISA的影响最大。
