前列腺素的可能作用方式。十二。前列腺素F2α对完整和去势妊娠大鼠诱导胚胎过早排出的不同作用。

The possible mode of action of phostaglandins. XII. Differential effects of phostaglandin F2alpha in inducing premature evacuation of conceptos in the intact and castrated pregnant rat.

作者信息

Chatterjee A

出版信息

Prostaglandins. 1976 Dec;12(6):1053-9. doi: 10.1016/0090-6980(76)90138-6.

Abstract

A single injection of 2.0 mg/kg prostaglandin F2alpha(PGF2alpha) on day 18 of pregnancy was consistent in inducing premature labor by 72 h following the injection. Conversely, castration before PGF2alpha on day 18 of pregnancy made the animals almost inert to PGF2alpha and only 20% of the treated animals showed premature evacuation of the conceptus. Injection of 10mug of estradiol cyclopentylpropionate (ECP) on day 18 was, however, found to be effective in emptying the gravid uteri of 100% castrated pregnants by 72 h. Indomethacin, a consistent inhibitor of prostaglandin biosynthesis and release, along with ECP in an identical experimental situation was found to be ineffective in reversing the ECP-induced premature parturition in castrated pregnants. The importance of intact ovary for the action of PGF2alpha concerning premature labor in rats has been discussed.

摘要

在妊娠第18天单次注射2.0毫克/千克前列腺素F2α（PGF2α）可使注射后72小时内早产情况一致。相反，在妊娠第18天于注射PGF2α之前进行去势，会使动物对PGF2α几乎无反应，只有20%的受试动物出现胚胎过早排出。然而，在妊娠第18天注射10微克环戊丙酸雌二醇（ECP）被发现可使100%去势妊娠动物的妊娠子宫在72小时内排空。在相同实验情况下，吲哚美辛是一种持续的前列腺素生物合成和释放抑制剂，与ECP一起使用时，发现其在逆转去势妊娠动物中由ECP诱导的早产方面无效。文中讨论了完整卵巢对于PGF2α在大鼠早产作用中的重要性。