美替拉酮对体外培养的妊娠大鼠子宫前列腺素合成与释放的影响。
The influence of metyrapone on the synthesis and release of prostaglandins from the pregnant rat uterus in vitro.
作者信息
Parnham M J, Sneddon J M
出版信息
Br J Pharmacol. 1975 Dec;55(4):535-9. doi: 10.1111/j.1476-5381.1975.tb07429.x.
Abstract
1 Metyrapone (150 mg/kg, s.c. or i.p.) an inhibitor of corticosteroid biosynthesis, significantly reduced the release of prostaglandins of the F-type from isolated preparations of pregnant rat uteri in vitro, on day 22 - the expected day of delivery. 2 Metyrapone and indomethacin administered in vitro both inhibited the conversion of 14C-arachidonic acid to prostaglandin E2 by homogenates of day 22 pregnant rat uteri. Metyrapone was approximately 150 times less potent than indomethacin. Although indomethacin also inhibited prostaglandin F2alpha production, metyrapone stimulated synthesis of this prostaglandin. The differential inhibition of prostaglandin synthesis by metyrapone may reflect sensitivity of the inhibitor to changes in experimental conditions. 3 Inhibition of prostaglandin synthesis may explain the effects of metyrapone on parturition in the rat.
摘要
- 甲吡酮（150毫克/千克，皮下注射或腹腔注射）是一种皮质类固醇生物合成抑制剂，在预期分娩日（第22天），它能显著减少体外分离的妊娠大鼠子宫制剂中F型前列腺素的释放。2. 体外给予甲吡酮和吲哚美辛均能抑制第22天妊娠大鼠子宫匀浆将14C-花生四烯酸转化为前列腺素E2。甲吡酮的效力约为吲哚美辛的1/150。虽然吲哚美辛也抑制前列腺素F2α的产生，但甲吡酮却刺激这种前列腺素的合成。甲吡酮对前列腺素合成的不同抑制作用可能反映了该抑制剂对实验条件变化的敏感性。3. 前列腺素合成的抑制可能解释了甲吡酮对大鼠分娩的影响。
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引用本文的文献
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Effects of metyrapone on rat uterine prostaglandin release and on spontaneous smooth muscle activity in vitro [proceedings].甲吡酮对大鼠子宫前列腺素释放及体外自发性平滑肌活动的影响[会议论文集]
Br J Pharmacol. 1976 Jul;57(3):465P-466P.
2
Cyclic AMP and prostaglandin E in perfusates of rat hind paws during the development of adjuvant arthritis.佐剂性关节炎发展过程中大鼠后爪灌注液中的环磷酸腺苷和前列腺素E
Ann Rheum Dis. 1978 Jun;37(3):218-24. doi: 10.1136/ard.37.3.218.
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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