Ruppert B, Wei W, Medina D, Heppner G H
J Natl Cancer Inst. 1978 Oct;61(4):1165-9.
The experiments reported herein examined the effects of chemical carcinogen treatment of precursor hyperplastic alveolar nodules on the immunogenicity of subsequent mammary tumors in mice. The results of in vitro immunogenicity assays were compared with those of in vivo transplantation resistance tests. This comparison demonstrated that the in vitro assays predicted qualitatively and quantitatively the results from the in vivo test. In addition, the data suggested that the immunogenicity of a tumor depends on events occurring during the development of precursor hyperplastic alveolar nodules rather than during the development of subsequent mammary tumors.
本文所报道的实验研究了化学致癌物处理前体增生性肺泡结节对小鼠后续乳腺肿瘤免疫原性的影响。将体外免疫原性分析的结果与体内移植抗性试验的结果进行了比较。这种比较表明，体外分析在质量和数量上都能预测体内试验的结果。此外，数据表明，肿瘤的免疫原性取决于前体增生性肺泡结节发育过程中发生的事件，而不是后续乳腺肿瘤发育过程中发生的事件。
