Rönnemaa T
Scand J Gastroenterol. 1976;11(8):849-55.
Rats were fed a high cholesterol, olive oil diet for one or seven weeks. The resulting hypertrophic fatty livers were analyzed for lipids, nucleic acids, and connective tissue components. The cholesterol and neutral glyceride contents of liver increased approximately 30-fold during the first week while phospholipids remained almost unchanged. After seven weeks the accumulation of cholesterol was further increased and the content of phospholipids enhanced. The total amounts of DNA and RNA rose with increasing weight of fatty liver. In seven weeks the diet caused a marked increase in hepatic collagen and glycosaminoglycans. The synthesis of collagen was increased in fatty liver slices after both one and seven weeks of the experiment. Fatty liver produced by this lipid diet is suggested as a suitable model for studying the mechanism by which lipids stimulate hepatic fibroblasts.
给大鼠喂食高胆固醇橄榄油饮食1周或7周。对由此产生的肥大性脂肪肝进行脂质、核酸和结缔组织成分分析。肝脏中的胆固醇和中性甘油酯含量在第一周增加了约30倍，而磷脂几乎保持不变。7周后，胆固醇的积累进一步增加，磷脂含量增加。DNA和RNA的总量随着脂肪肝重量的增加而增加。7周后，这种饮食导致肝脏胶原蛋白和糖胺聚糖显著增加。在实验1周和7周后，脂肪肝切片中胶原蛋白的合成均增加。这种脂质饮食产生的脂肪肝被认为是研究脂质刺激肝成纤维细胞机制的合适模型。
