Ivancevic V
Klinik für Nuklearmedizin, Universitätsklinikum Charité, Humboldt Universität zu Berlin.
Zentralbl Chir. 1998;123 Suppl 5:53-6.
Position emission tomography (PET) offers new opportunities in the non-invasive diagnosis and therapy monitoring of breast cancer. So far, PET with the glucose analogue fluorodeoxyglucose is investigated best, especially in diagnosing the primary tumour and in staging axillary lymph nodes. The validity of the method in staging distant metastases and monitoring therapy is also being investigated. At the moment, few data is available on PET with C-11-methionin as well as on PET with more specific radiopharmaceuticals like I-124-labelled monoclonal antibodies and F-18-labelled estrogen receptor ligands. This short review presents the state of the art of PET in the diagnostics and therapy monitoring of breast cancer.
正电子发射断层扫描(PET)为乳腺癌的无创诊断和治疗监测提供了新机遇。到目前为止,对使用葡萄糖类似物氟脱氧葡萄糖的PET研究得最为充分,尤其是在诊断原发性肿瘤和对腋窝淋巴结进行分期方面。该方法在对远处转移灶进行分期及监测治疗方面的有效性也在研究中。目前,关于使用C-11-蛋氨酸的PET以及使用更具特异性的放射性药物(如I-124标记的单克隆抗体和F-18标记的雌激素受体配体)的PET的可用数据较少。这篇简短的综述介绍了PET在乳腺癌诊断和治疗监测方面的最新进展。