Malaty H M, Graham D Y, Wattigney W A, Srinivasan S R, Osato M, Berenson G S
Department of Laboratory Medicine, Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA.
Clin Infect Dis. 1999 Feb;28(2):279-82. doi: 10.1086/515105.
We assessed the pattern of acquisition and loss of Helicobacter pylori infection in a cohort of 212 children from a biracial community with a homogeneous socioeconomic class. The children were followed over 12 years (1973-1974 to 1985-1986) from childhood to young adulthood. H. pylori status was assessed by the presence of serum IgG antibodies to H. pylori. At ages 7-9, 19% of children had H. pylori infection (40% of blacks vs. 11% of whites; P = .0001); 12 years later, 33% were seropositive. The higher prevalence among blacks remained (P = .0001). During follow-up, 22% of children became infected; the rate of acquisition was fourfold greater among blacks than among whites (P = .001). Over the 12-year period, infection was lost in 50% of whites compared with 4% of blacks who either remained infected or became reinfected. H. pylori infection in childhood is affected by both acquisition and loss of infection in different ethnic groups. This observation is critical for understanding the epidemiology and transmission of H. pylori infection.
我们评估了来自一个社会经济阶层同质化的混血社区的212名儿童幽门螺杆菌感染的获得和丧失模式。这些儿童从童年到青年期被随访了12年（1973 - 1974年至1985 - 1986年）。通过检测血清中幽门螺杆菌IgG抗体来评估幽门螺杆菌感染状况。在7至9岁时，19%的儿童有幽门螺杆菌感染（黑人中为40%，白人中为11%；P = 0.0001）；12年后，33%的儿童血清学呈阳性。黑人中的较高患病率仍然存在（P = 0.0001）。在随访期间，22%的儿童被感染；黑人的感染获得率是白人的四倍（P = 0.001）。在这12年期间，50%的白人感染消失，而黑人中只有4%的人感染消失或再次感染。儿童期的幽门螺杆菌感染受不同种族感染的获得和丧失的影响。这一观察结果对于理解幽门螺杆菌感染的流行病学和传播至关重要。
