Roosendaal G, van Rinsum A C, Vianen M E, van den Berg H M, Lafeber F P, Bijlsma J W
The Van Creveld Clinic, Department of Rheumatology & Clinical Immunology, University Medical Centre Utrecht, The Netherlands.
Histopathology. 1999 Feb;34(2):144-53. doi: 10.1046/j.1365-2559.1999.00608.x.
To investigate the pathogenetic mechanisms of haemophilic arthropathy (HA) by comparing end-stage arthropathy with osteoarthritis (OA; a degenerative joint disorder) and rheumatoid arthritis (RA; an inflammation-mediated joint disease).
Cartilage and synovium from patients with HA (n=10), RA (n=8), OA (n=14) and normal control subjects (n=6) were examined morphologically, biochemically and histochemically. Cartilage in HA exhibited characteristics of degenerative joint disease (OA), as evidenced by morphological, histochemical (Safranin-O fast green-iron haematoxylin, Mankin grade) and biochemical (proteoglycan synthesis, glycosaminoglycan content and DNA content) changes, whereas synovium in HA showed characteristics of inflammation-mediated joint disease (RA), as evidenced by histochemical (inflammation, haematoxylin and eosin (H&E) and iron deposition, Perls' blue) and biochemical changes (interleukin (IL)-1, IL-6, tumour necrosis factor (TNF)alpha and catabolic properties).
Haemophilic arthropathy shows characteristics of both inflammatory and degenerative joint disease. On the basis of these results and published information, it appears that degenerative cartilage changes have a dominant role in HA and are augmented by relatively mild inflammation of the synovium.
通过比较终末期关节病与骨关节炎（OA；一种退行性关节疾病）和类风湿关节炎（RA；一种炎症介导的关节疾病），研究血友病性关节病（HA）的发病机制。
对HA患者（n = 10）、RA患者（n = 8）、OA患者（n = 14）及正常对照者（n = 6）的软骨和滑膜进行形态学、生物化学和组织化学检查。HA中的软骨表现出退行性关节病（OA）的特征，形态学、组织化学（番红O - 固绿 - 铁苏木精染色、曼金分级）和生物化学（蛋白聚糖合成、糖胺聚糖含量和DNA含量）变化均证实了这一点；而HA中的滑膜表现出炎症介导的关节疾病（RA）的特征，组织化学（炎症、苏木精和伊红（H&E）染色及铁沉积、普鲁士蓝染色）和生物化学变化（白细胞介素（IL）-1、IL - 6、肿瘤坏死因子（TNF）α及分解代谢特性）均证实了这一点。
血友病性关节病表现出炎症性和退行性关节疾病的特征。基于这些结果及已发表的信息，似乎退行性软骨变化在HA中起主导作用，并因滑膜相对轻微的炎症而加剧。
