Hosten N, Puls R, Lemke A J, Steger W, Zendel W, Zwicker C, Felix R
Humboldt Universität zu Berlin, Charité, Strahlenklinik und Poliklinik, Germany.
J Clin Ultrasound. 1999 Mar-Apr;27(3):107-15. doi: 10.1002/(sici)1097-0096(199903/04)27:3<107::aid-jcu2>3.0.co;2-y.
The aim of this study was to evaluate whether intravenous injection of an ultrasound contrast agent aids in the visualization of focal liver lesions on power Doppler images.
Fifty patients with focal liver lesions were studied by B-mode and power Doppler sonography before and after intravenous injection of the contrast agent Levovist (galactose-based microbubbles; 10 ml of a concentration of 300 mg/ml). Thirty-two patients had malignant liver lesions (19 metastases, 12 hepatocellular carcinomas, 1 cholangiocellular carcinoma), while 18 had benign lesions (12 hemangiomas, 2 focal nodular hyperplasias, 4 others).
After contrast medium injection, the number of lesions with no intralesional flow dropped from 18 to 9. Flow signal intensity was rated subjectively as marked on contrast-enhanced images in 17 patients; only 4 patients had marked flow on precontrast images. On precontrast studies, central flow in 10 lesions and peripheral flow in 29 lesions could be observed. After enhancement, the numbers increased to 18 and 34 lesions, respectively.
On power Doppler images, a greater number of intratumoral vessels are seen in focal liver lesions after contrast medium administration.
本研究旨在评估静脉注射超声造影剂是否有助于在能量多普勒图像上显示肝脏局灶性病变。
对50例肝脏局灶性病变患者在静脉注射造影剂Levovist（基于半乳糖的微泡；10ml浓度为300mg/ml）前后进行B超和能量多普勒超声检查。32例患者患有肝脏恶性病变（19例转移瘤、12例肝细胞癌、1例胆管细胞癌），18例患有良性病变（12例血管瘤、2例局灶性结节性增生、4例其他病变）。
注射造影剂后，病灶内无血流信号的病变数量从18个降至9个。在17例患者的造影增强图像上，血流信号强度主观评分为明显增强；造影前图像上只有4例患者有明显血流信号。在造影前检查中，可观察到10个病灶有中央血流，29个病灶有周边血流。增强后，数量分别增加到18个和34个病灶。
在能量多普勒图像上，肝脏局灶性病变在注射造影剂后可见更多的瘤内血管。
