Ernst H, Hahn E G, Balzer T, Schlief R, Heyder N
Department of Medicine I, University of Erlangen-Nuremberg, Erlangen, Germany.
J Clin Ultrasound. 1996 Jan;24(1):31-5. doi: 10.1002/(SICI)1097-0096(199601)24:1<31::AID-JCU5>3.0.CO;2-M.
Patients with focal liver lesions (hemangioma, focal nodular hyperplasia, adenoma, hepatocellular carcinoma, metastatic lesions, focal fatty lesion) received the ultrasound contrast agent Levovist (300 mg/mL and 400 mg/mL) intravenously. This ultrasound contrast agent (a suspension of micrometer-sized microparticles of galactose and microscopic gaseous bubbles) can pass through the lungs without impairment. After the administration of Levovist, increased color flow signals were detected in the liver. Five of 6 patients with metastatic liver lesions showed previously undetected blood flow in the rim of the tumor. In 4 patients with hepatocellular carcinoma, enhanced signal intensity was observed in the vessels of the rim and in 3 of those patients in the center of the tumor. One patient with adenoma and one patient with focal nodular hyperplasia showed signal enhancement in the central area of the tumor. No signal enhancement was observed in hemangiomas, a focal fatty lesion, or in a carcinoid metastatic lesion. Levovist increased the echointensity of normal and tumor vessels in liver lesions. This new ultrasound contrast agent led to the detection of tumor vessels previously not detectable by conventional color flow imaging.
患有局灶性肝病变（血管瘤、局灶性结节性增生、腺瘤、肝细胞癌、转移瘤、局灶性脂肪病变）的患者静脉注射超声造影剂声诺维（300mg/mL和400mg/mL）。这种超声造影剂（一种由微米级半乳糖微粒和微小气泡组成的混悬液）可无损通过肺部。注射声诺维后，肝脏内检测到彩色血流信号增强。6例肝转移瘤患者中有5例在肿瘤边缘显示出先前未检测到的血流。4例肝细胞癌患者在肿瘤边缘血管以及其中3例患者的肿瘤中心观察到信号强度增强。1例腺瘤患者和1例局灶性结节性增生患者在肿瘤中心区域显示信号增强。血管瘤、局灶性脂肪病变或类癌转移瘤未观察到信号增强。声诺维增加了肝脏病变中正常血管和肿瘤血管的回声强度。这种新型超声造影剂能够检测出传统彩色血流成像之前无法检测到的肿瘤血管。
