Dieleman J P, Hillebrand-Haverkort M E, van der Ende M E, Sturkenboom M C, Lange J M, Stricker B H
Sectie Farmaco-epidemiologie van de afdelingen Epidemiologie en Biostatistiek en Inwendige Geneeskunde, Erasmus Medisch Centrum, Rotterdam.
Ned Tijdschr Geneeskd. 1998 Dec 26;142(52):2856-60.
In three patients, a 36-year-old HIV seropositive homosexual man and two women aged 35 and 59 years who had acquired HIV infection through heterosexual contact, signs of lipodystrophy developed after prolonged anti-HIV triple therapy. The observed syndrome is seen after prolonged use of HIV protease inhibitors: it is characterized by peripheral fat wasting, central fat accumulation, hyperlipidaemia and insulin resistance. Typically the subcutaneous fatty tissue disappears resulting in prominent zygomata, veins and muscles and thinning of extremities and buttocks. In addition to abdominal fat accumulation, there have been reports on the occurrence of a dorsocervical fat pad, the so-called buffalo hump. Lipodystrophy caused by protease inhibitors is a risk factor for cardiovascular disease. Recognition of the syndrome is essential for adequate follow-up and possible treatment.
在三名患者中，一名36岁的HIV血清阳性同性恋男性以及两名分别为35岁和59岁通过异性接触感染HIV的女性，在长期接受抗HIV三联疗法后出现了脂肪代谢障碍的体征。长期使用HIV蛋白酶抑制剂后会出现这种观察到的综合征：其特征为外周脂肪消耗、中央脂肪堆积、高脂血症和胰岛素抵抗。通常皮下脂肪组织消失，导致颧骨、静脉和肌肉突出，四肢和臀部变细。除腹部脂肪堆积外，还有关于颈背脂肪垫（即所谓的水牛背）出现的报道。蛋白酶抑制剂引起的脂肪代谢障碍是心血管疾病的一个危险因素。识别该综合征对于充分的随访和可能的治疗至关重要。
