Wang Q S, Zhang L, Yang H Z, Liu H Y
National Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, People's Republic of China.
J Chromatogr Sci. 1999 Feb;37(2):41-4. doi: 10.1093/chromsci/37.2.41.
The retention characteristics of 25 2-cyano-3-methylthio-3-substituted amine-acrylates are determined using reversed-phase thin-layer chromatography (RP-TLC) with methanol-water mixtures as eluents. The relationship between Rm values and partition coefficients (C log P) are established. The Rm values decrease linearly with increasing methanol concentration in the eluent. The Rm values extrapolated to zero organic modifier concentration (Rm0) in the eluent are highly related to C log P. The Rm0 value can be used to evaluate the lipophilicity of this kind of compound.
以甲醇 - 水混合物作为洗脱剂，采用反相薄层色谱（RP - TLC）法测定了25种2 - 氰基 - 3 - 甲硫基 - 3 - 取代胺基丙烯酸酯的保留特性。建立了比移值（Rm）与分配系数（C log P）之间的关系。洗脱剂中甲醇浓度增加时，Rm值呈线性下降。将洗脱剂中有机改性剂浓度外推至零（Rm0）时的Rm值与C log P高度相关。Rm0值可用于评估这类化合物的亲脂性。
