通过药物注射使皮层下位点可逆失活。
Reversible inactivation of subcortical sites by drug injection.
作者信息
Malpeli J G
机构信息
Department of Psychology, University of Illinois, Champaign 61820, USA.
出版信息
J Neurosci Methods. 1999 Jan;86(2):119-28. doi: 10.1016/s0165-0270(98)00161-7.
Abstract
Reversible inactivation of subcortical targets by means of drug injections has been a powerful tool for revealing the contributions of discrete brain structures to behavior and the functional organization of the brain. This paper is intended to provide practical advice on this approach, including the choice of drug, means of delivering drugs, strategies for evaluating the action of injected drugs, and the application of this method to experiments with awake animals.
摘要
通过药物注射实现皮层下靶点的可逆失活，一直是揭示离散脑结构对行为的贡献以及大脑功能组织的有力工具。本文旨在为这种方法提供实用建议，包括药物选择、给药方式、评估注射药物作用的策略，以及该方法在清醒动物实验中的应用。
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