Steeg P S, Zhou Q
Women's Cancers Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, MD 20892, USA.
Breast Cancer Res Treat. 1998;52(1-3):17-28. doi: 10.1023/a:1006102916060.
Cyclins are regulatory subunits for cyclin dependent kinases in the coordination of the cell cycle. Cyclins can also serve non-cell cycle functions, such as the transactivation of estrogen receptor by cyclin D. Evidence for the participation of the G1 cyclins D and E in breast cancer is summarized, including transgenic and knockout mice, transfections, and expression patterns in cohort studies. Overexpression of cyclin D has been reported in ductal carcinoma in situ (DCIS), and similar overexpression of cyclin E is suggested. Strategies to reduce cyclin expression are discussed as potential prevention efforts.
细胞周期蛋白是细胞周期蛋白依赖性激酶的调节亚基，用于协调细胞周期。细胞周期蛋白还可发挥非细胞周期功能，如细胞周期蛋白D对雌激素受体的反式激活作用。总结了G1期细胞周期蛋白D和E参与乳腺癌的证据，包括转基因和基因敲除小鼠、转染以及队列研究中的表达模式。导管原位癌（DCIS）中已报道细胞周期蛋白D过表达，提示细胞周期蛋白E也有类似的过表达。讨论了降低细胞周期蛋白表达的策略，作为潜在的预防措施。
